The cumulative impact curve in Pareto Analysis is significant as it helps in determining which accounts to prioritize. It represents the cumulative effect of the top accounts on the total revenue. By focusing on the account that has the highest cumulative impact, managers can achieve the highest percentage of positive Return on Investment (ROI). This curve is a visual tool that assists in distinguishing the 'vital few' accounts from the 'trivial many', thereby guiding resource allocation and strategic decision-making.
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